The Catholic University of America

 Byung Min (Justin) Chung

Assistant Professor

   

    Room: Nursing-Biology 356

    Phone: (202) 319-5279

    E-mail: chung@cua.edu 

   

 

 

 

 

 

 

 

 

Education and Training:

B.S. Chemistry with specialization in Biochemistry, University of Virginia

Ph.D. Cancer Research, Northwestern University

Postdoctoral Fellow, Biochemistry and Molecular Biology, Johns Hopkins School of Public Health

 

Teaching Interests:

Introductory Biology

Cell Structure and Function

Cancer Biology

 

Research Interests

 

The major focus of my laboratory is to elucidate novel functions of keratins in cancer cells. Intermediate filament proteins are the most diverse cytoskeleton proteins, and keratin family of intermediate filament proteins are abundantly expressed in all epithelial cells. Keratins, like all intermediate filament proteins, form ~10 nm wide filaments and provide crucial structural support upon mechanical and non-mechanical stresses. Interestingly, recent studies have revealed several non-mechanical support functions for keratins including cell migration and proliferation.

In cancer, an aberrant expression of keratins is frequently observed, and keratin expression has diagnostic and even prognostic value. We previously demonstrated that keratins contribute towards cancer cell proliferation and invasion by regulating gene expression through an interaction with an RNA-binding protein. My laboratory investigates the cellular roles, regulation and mechanisms of actions of keratins in the context of various metastatic cancers.

 

Publications:

1.     Reddy AL, Duan L, Rainey MA, Ortega-Cava C , Clubb R, Chung BM, Dimri M, Tu C, George M, Raja S, Naramura M, Band V, Band H. Cbl- family E3 Ubiquitin Ligases as Regulators of Non-Receptor Tyrosine Kinases; chapter in  Cbl Proteins. Tsygankov A. (ed). 2008, p. 53 - 74. Nova Science Publishers, Inc. New York. ISBN 9781604561685

2.     Chung BM, Dimri M, George M, Reddi AL, Chen G, Band V, Band H.  The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants.  Oncogene. 2009. 28(16):1821-32

3.      Chung BM, Raja SM, Clubb RJ, Tu C, George M, Band V, Band H.  Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src. BMC Cell Biology. 2009. 10:84

4.     Duan L, Chen G, Virmani S, Ying G, Raja SM, Chung BM, Rainey MA, Dimri M, Ortega-Cava CF, Zhao X, Clubb RJ, Tu C, Reddi AL, Naramura M, Band V, Band H.  Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture.  Journal of Biological Chemistry. 2010. 285(2):1555-68

5.     Tu C, Ahmad G, Mohapatra B, Bhattacharyya S, Ortega-Cava CF, Chung BM, Wagner KU, Raja SM, Naramura M, Band V, Band H. ESCRT proteins: Double-edged regulators of cellular signaling. Bioarchitecture. 2011. 1(1):45-48.

6.     Chung BM. Endocytic regulation of EGFR Signaling. Interdisciplinary Bio Central. 2012. 4(3):1-7

7.     Chung BM, Murray CI, Van Eyk JE, Coulombe PA. Novel interaction and reciprocal regulation between annexin A2 and keratin 17. Journal of Biological Chemistry. 2012. 287(10):7573-81

8.     Lee CH, Kim MS, Chung BM, Leahy DJ, Coulome PA. Structural basis for heterodimeric assembly and perinuclear organization of keratin filaments. Nature Structural and Molecular Biology. 2012. 19(7):707-15

9.     Chung BM, Rotty JR, Coulombe PA. Networking Galore: Intermediate filaments and cell migration. Current Opinion in Cell Biology. 2013. 25(5):600-12

10.  Chung BM, Tom E, Zutshi N, Bielecki TA, Band V, Band H. Nexus of Signaling and Endocytosis in Oncogenesis Driven by NSCLC-associated EGFR mutants. World Journal of Clinical Oncology. 2014. 5(5):806-23

11. Chung BM, Arutyunov A, Ilagan E, Yao N, Wills-Karp M, Coulombe PA. Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes. Journal of Cell Biology. 2015 Mar 2;208(5):613-27.

12.  Hobbs RP, DePianto D, Jacob JT, Han MC, Chung BM, Batazzi AS, Poll BG, Guo Y, Han J, Ong S, Zheng W, Taube JM, ?iháková D, Wan F, Coulombe PA. Keratin-dependent regulation of autoimmune regulator (Aire) and gene expression in skin tumor keratinocytes. Nature Genetics. In press